DE CLEYN, MICHEL ANNA JOZEF,VAN BRANDT, SVEN FRANCISCUS ANNA,GIJSEN, HENRICUS JACOBUS MARIA,BERTHELOT, DIDIER JEAN-CLAUDE,OEHLRICH, DANIEL
申请号：
ES11700171
公开号：
ES2512840T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula (I) or a stereoisomeric form thereof, in which: Het1 is a heterocycle, having the formula (a-1), (a-2), (a-3) or (a-4) R3 it is C1-4 alkyl； R4, R5, R6 and R8 are each independently hydrogen or C1-4 alkyl optionally substituted with one or more halo substituents； R7a is hydrogen, halo or C1-4 alkyl； R7b and R7c are each independently hydrogen, halo, cyano, C1-4 alkyloxy, C3-7 cycloalkyl or C1-4 alkyl optionally substituted with one or more halo substituents； Xa is CH or N； Xb is O or S； A1 is CR9 or N； wherein R9 is hydrogen, halo or C1-4 alkyloxy； A2, A3 and A4 are each independently CH or N； provided that at most two of A1, A2, A3 and A4 are N； L1 is O, carbonyl, NR10, NH- (C>； = O) or (C>； = O) -NH； wherein R10 is hydrogen or C1-4 alkyl； R1 and --L2-R2 are taken together to form a bivalent radical --R1-R2-L2-- having the formula (b-1), (b-2), (b-3), (b-4 ), (b-5), (b-6) or (b-7) - (CH2) mnY- (CH2) n-- (b-1)； - (CH2) n-Y- (CH2) m-n-- (b-2)； --CH>； = CH-CH>； = CH-- (b-3)； --CH>； = CH-N>； = CH-- (b-4)； --CH>； = N-CH>； = CH-- (b-5)； - (CH2) q-r-Y- (CH2) r-1,2-benzenediyl-- (b-6)； - (CH2) rY- (CH2) q-r-1,2-benzenediyl-- (b-7)； in which (b-1) or (b-2) may contain an unsaturated bond；Compuesto de fórmula (I) o una forma estereoisomérica del mismo, en la que: Het1 es un heterociclo, que tiene la fórmula (a-1), (a-2), (a-3) o (a-4) R3 es alquilo C1-4； R4, R5, R6 y R8 son cada uno independientemente hidrógeno o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes halo； R7a es hidrógeno, halo o alquilo C1-4； R7b y R7c son cada uno independientemente hidrógeno, halo, ciano, alquiloxilo C1-4, cicloalquilo C3-7 o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes halo； Xa es CH o N； Xb es O o S； A1 es CR9 o N； en el que R9 es hidrógeno, halo o alquiloxilo C1-4； A2, A3 y A4 son cada uno independientemente CH o N； siempre que como máximo dos de A1, A2, A3 y A4 sean N； L1 es O, carbonilo, NR10, NH-(C>；=O) o (C>；=O
