VANDYCK, KOEN,VERSCHUEREN, WIM GASTON,RABOISSON, PIERRE JEAN-MARIE BERNARD
申请号：
ES11740622
公开号：
ES2504977T3
申请日:
2011.07.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I: or a stereoisomer thereof, wherein: each of is, independently, pyrrolidin-2-yl, 2-aza-bicyclo [3.1.0] hexan-3-yl, piperidin-2-yl, 2-azabicyclo [2.2.1] heptan-2-yl or octahydro-1H-indole-2-yl, wherein each of said heterocycles may be optionally substituted with one or more halogen atoms； is CR4>； = C-NH, NH-C>； = CH or NH-C>； = N； X1 is CH and X2 is CH； or X1 is CH and X2 is N； or X1 is N and X2 is CH； W is carbonyl, sulfonyl or CR5R6； R and R 'are independently selected from -CR1R2R3, aryl optionally substituted with 1 or 2 substituents selected from halo and methyl, or heterocycloalkyl, wherein R1 is selected from C1-4 alkyl optionally substituted with methoxy, hydroxy or dimethylamino； C3-6 cycloalkyl； tetrahydropyranyl； phenyl optionally substituted with 1, 2 or 3 substituents independently selected from halo, C1-4 alkoxy, trifluoromethoxy, or 2 substituents on adjacent ring atoms form a 1,3-dioxolane group； benzyl optionally substituted with halo or methoxy； heteroaryl； and heteroarylmethyl； R 2 is selected from hydrogen, hydroxy, amino, mono- or di-C 1-4 alkyl, (C 3-6 cycloalkyl) (C 1-4 alkyl) amino, C 1-4 alkylcarbonylamino, phenylamino, C 1-4 alkylcarbonylamino, (alkyl C1-4oxycarbonyl) (C1-4alkyl) amino, C1-4alkylcarbonylamino, tetrahydro-2-oxo-1 (2H) -pyrimidinyl, pyrrolidin 1-yl, piperidin-1-yl, 3,3-difluoropiperidin-1-yl , morpholin-1-yl, 7-azabicyclo [2.2.1] hept-7-yl and imidazol-1-yl； and R3 is hydrogen or C1-4 alkyl, or CR2R3 together form carbonyl； or CR1R3 forms a cyclopropyl group； R4 is hydrogen, C1-4 alkyl or cyano； R5 and R6, each independently, are C1-4 alkyl； or CR5R6 together form C3-7 cycloalkyl, oxetane, tetrahydrofuran； or pharmaceutically acceptable salts or a solvate thereof.Un compuesto de fórmula I: o un estereoisómero del mismo, en donde: cada uno de es, independientemente, pirrolidin-2-ilo, 2-aza-biciclo[3.1.0]hexan-3-ilo, piperidin-2-ilo, 2-azabiciclo[ 2.2.1]heptan-2-ilo u octahidro-1H-indol-2-ilo, en d
