Pyrazole-carboxamide derivatives as TAAR modulators for use in the treatment of various disorders, such as depression, diabetes and Parkinson's disease
A compound of formula ** Formula ** in which R 1 is phenyl, optionally substituted with halogen, C 1-7 alkyl, C 3-6 cycloalkyl, C 1-7 alkoxy, cyano, C 1-7 alkyl substituted by halogen, C 1-7 alkyl substituted by hydroxy, C1-7 alkoxy substituted by halogen or C1-7 alkoxy substituted by hydroxy； or is pyridin-2, 3 or 4-yl, optionally substituted with halogen, C 1-7 alkyl, C 3-6 cycloalkyl, cyano, C 1-7 alkyl substituted by halogen, C 1-7 alkyl substituted by hydroxyl, C 1-7 alkoxy, C1-7 alkoxy substituted with halogen, or C1-7 alkoxy substituted with hydroxyl； or is pyrimidin-2, 4 or 5-yl, optionally substituted with halogen, C1-7 alkyl, cycloalkyl-C3-6, C1-7 alkyl substituted with hydroxy or C1-7 alkyl substituted with halogen, or is pyrazine-2- ilo, optionally substituted with halogen, C1-7 alkyl, C3-6 cycloalkyl, C1-7 alkyl substituted with halogen, C1-7 alkyl substituted with hydroxy or cyano, or is 2,2-difluorobenzo [d] [1,3] dioxol-5-yl or is thiazolyl, optionally substituted with halogen substituted C1-7 alkyl； R2 is hydrogen or C1-7 alkyl； R3 is hydrogen, amino or C1-7 alkyl； Z is a bond, -CH2- or -O-； or a pharmaceutically suitable acid addition salt thereof.Un compuesto de fórmula **Fórmula** en la que R1 es fenilo, opcionalmente sustituido con halógeno, alquilo C1-7, cicloalquilo C3-6, alcoxi C1-7, ciano, alquilo C1-7 sustituido con halógeno, alquilo C1-7 sustituido con hidroxi, alcoxi C1-7 sustituido con halógeno o alcoxi C1-7 sustituido con hidroxi； o es piridin-2, 3 o 4-ilo, opcionalmente sustituido con halógeno, alquilo C1-7, cicloalquilo C3-6, ciano, alquilo C1-7 sustituido con halógeno, alquilo C1-7 sustituido con hidroxilo, alcoxi C1-7, alcoxi C1-7 sustituido con halógeno, o alcoxi C1-7 sustituido con hidroxilo； o es pirimidin-2, 4 o 5-ilo, opcionalmente sustituido con halógeno, alquilo C1-7, cicloalquilo-C3-6, alquilo C1-7 sustituido con hidroxi o alquilo C1-7 sustituido con halógeno, o es pirazin-2- ilo, opcionalmente sustituido con halógeno, alqui
