GALLEY, GUIDO,NORCROSS, ROGER,PFLIEGER, PHILIPPE,TRUSSARDI, RENÉ
申请号：
ES12727633
公开号：
ES2546529T3
申请日:
2012.06.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula ** Formula ** in which: R 1 is hydrogen, halogen, cyano, C 1-7 alkyl, C 1-7 alkyl substituted by halogen, C 1-7 alkoxy, C 1-7 alkoxy substituted by halogen or C ( O) NH2, or is phenyl optionally substituted by halogen, cyano or C1-7 alkoxy substituted by halogen, or is 2,2-difluorbenzo [d] [1,3] dioxol-5-yl, or is 6- (trifluoromethyl) -pyrazin-2-yl or 5- (trifluoromethyl) pyrazin-2-yl or is 6- (trifluoromethyl) pyrimidin-4-yl, or is 6- (trifluoromethyl) -pyridin-3-yl, or is 5-cyanopyrazine- 2-yl or is 2- (trifluoromethyl) pyrimidin-4-yl； n is the number 1 or 2 R2 is halogen, C1-7 alkyl or cyano and R3 is hydrogen, or R2 is hydrogen and R3 is halogen, C1-7 alkyl or cyano； X is a bond, -NR'-, -CH2NH- or -CHR'-； R 'is hydrogen or C1-7 alkyl； Z is a bond, -CH2- or -O-； Ar is phenyl or is heteroaryl selected from the group consisting of 1H-indazol-3-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, 1H-pyrazole-3- ilo, 1H-pyrazol-4-yl and 1H-pyrazol-5-yl； and the compound (S) -N- (3-fluoro-4- (morpholin-2-yl) phenyl) -5-trifluoromethyl) pyrazin-2-carboxamide, or a pharmaceutically appropriate acid addition salt thereof.Un compuesto de la fórmula**Fórmula** en la que: R1 es hidrógeno, halógeno, ciano, alquilo C1-7, alquilo C1-7 sustituido por halógeno, alcoxi C1-7, alcoxi C1-7 sustituido por halógeno o C(O)NH2, o es fenilo opcionalmente sustituido por halógeno, ciano o alcoxi C1-7 sustituido por halógeno, o es 2,2- difluorbenzo[d][1,3]dioxol-5-ilo, o es 6-(trifluormetil)-pirazin-2-ilo o 5-(trifluormetil)pirazin-2-ilo o es 6- (trifluormetil)pirimidin-4-ilo, o es 6-(trifluormetil)-piridin-3-ilo, o es 5-cianopirazin-2-ilo o es 2-(trifluormetil) pirimidin-4-ilo； n es el número 1 ó 2 R2 es halógeno, alquilo C1-7 o ciano y R3 es hidrógeno, o R2 es hidrógeno y R3 es halógeno, alquilo C1-7 o ciano； X es un enlace, -NR'-, -CH2NH- o -CHR'-； R' es hidrógeno o alquilo C1-7； Z es un enlace, -CH2- u -O-； Ar es fenilo o es heteroarilo elegido entre e
