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Quinazoline Derivatives, antibacterial - 4 (3H) - One
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
申请号:
ARP150101482
公开号:
AR100428A1
申请日:
2015.05.13
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
Claim 1: a formula compound (1), wherein R 1 is h or halogen; R 2 is M group; R 3 is h or halogen; m is Ma and methyl bromide group, represented by formulas (2) and (3),where A represents a bond or C; R¹A is H or halogen; R²A is H, C₁₋₃ alkoxy or halogen; R³A is H, C₁₋₃ alkoxy,Oxyhydrogen c833228c83318324;Calcium hydroxide c83216c831832424;1,2-dihydroxy, diaklamino c833218331;1-hydroxymethyl-cycloprop-1-yl, 1 - ((dimethylglycyl) oxy) methyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, morpholin-4-yl-C₁₋₂ alkyl or morpholin-4-yl C₂₋₃ alkoxy;and R¹B is C₁₋₃ hydroxyalkyl,C₁₋₃ aminoalkyl,[C₁₋₃ dialkylamino] -C₁₋₃ alkyl,1,2-dihydroxypropy-3-yl, 1-amino-cycloprop-1-yl, 1-hydroxymethyl-cycloprop-1-yl, 1 - ((phosphonooxy) methyl) cycloprop-1-yl, trans-2-hydroxymethyl- cycloprop-1-yl, trans-2-aminomethyl-cycloprop-1-yl, 1-fluoro-2-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-1-methyl-cycloprop-1-yl, 2- fluoro-2-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-2-methyl-cycloprop-1-yl, 1- (1,2-dihydroxyethyl) -cycloprop-1-yl, trans-2- (1 , 2-dihydroxyethyl -) - cycloprop-1-yl, 1- (hydroxymethyl) cyclobut-1-yl, 3-hydroxyoxetan-3-yl, 3- (hydroxyalkyl C₁₋₃) oxetan-3-yl, 3-hydroxythietan- 3-yl, trans- (cis-3,4-dihydroxy) -cyclopent-1-yl, 3- (2-aminoacetamido) cyclopentyl,3-hydroxyethylene glycol [1,1,1,1] pentan-1-ilo or 3-hydroxoxan-3-ilmerhy; or a salt of this compound.Reivindicación 1: Un compuesto de fórmula (1) donde R¹ es H o halógeno; R² es el grupo M; R³ es H o halógeno; M es uno de los grupos MA y MB representados por las fórmulas (2) y (3), donde A representa un enlace o CºC; R¹A es H o halógeno; R²A es H, alcoxi C₁₋₃ o halógeno; R³A es H, alcoxi C₁₋₃, hidroxialcoxi C₂₋₄, hidroxialquilo C₁₋₄, 1,2-dihidroxietilo, dialquilamino C₁₋₃, 1-hidroximetil-cicloprop-1-ilo, 1-((dimetilglicil)oxi)metil-cicloprop-1-ilo, 3-hidroxioxetan-3-ilo, morfolin-4-il-alquilo C₁₋₂ o morfolin-4-il alcoxi C₂₋₃; y R¹B es hidroxialquilo C₁₋₃, aminoalquilo C₁₋₃, [dialquilamino C₁₋₃]-alquilo C₁₋₃,
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