OOST, THORSTEN,ANDERSKEWITZ, RALF,HAMPRECHT, DIETER WOLFGANG,HOENKE, CHRISTOPH,MARTYRES, DOMNIC,RIST, WOLFGANG,SEITHER, PETER
申请号：
PE0010222012
公开号：
PE15192012A1
申请日:
2011.01.24
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to pyrazole compounds of formula (i) where W is hidroxicarbonilo, tetrazol - 5 - ILO - 1,2,4 - Oxadiazoles 5 (4H) - on 3 - ILO, among others X is a rest carbociclico heterocycle or C6 selected between Fen - 1.4 - 2.5 - pyridin - full, full, among others optionally sustiuidos C1 is H, alkyl - 6 Cycloalkyl C3 - 8, phenyl, among others L1 is methylene, EthyleneEtenileno or acetylene where each carbon Atom in Methylene chloride or Ethylene optionally replaced by 1 or 2 is selected from Halogen, Hydroxy radical, among others L2 is methylene and ethylene in which each carbon Atom is optionally substituted by one or two selected Radicals ent Re Halogen, Hydroxy, among others L3 is - ch = CH -, - C (o) -,Among others, R1 and R2 are independently h, halogen, alkyl of C1 - C2 - alquenilo 6, 6, among others. Preferred compounds are: acid {3,5 Dimethyl 1 - [4 - (trifluoromethyl) - benzoylamino) benzyl] - 1h-pyrazol-4-yl] - acetic acid, 3 - [1 - (4 - benciloxicarbonilamino - benzyl) - 3.5 - dimethyl - 1h-pyrazol-4-yl] - propionic acid among others. In addition to such a Pharmaceutical composition.These compounds are useful as CRTH2 antagonists in the treatment of respiratory diseases, gastrointestinal, inflammatory, AllergicSE REFIERE A COMPUESTOS DE PIRAZOL DE FORMULA (I) DONDE: W ES HIDROXICARBONILO, TETRAZOL-5-ILO 1,2,4-OXADIAZOL-5(4H)-ON-3-ILO, ENTRE OTROS X ES UN RESTO CARBOCICLICO O HETEROCICLICO C6 SELECCIONADOS ENTRE FEN-1,4-ILENO, PIRIDIN-2,5-ILENO, ENTRE OTROS OPCIONALMENTE SUSTIUIDOS Y ES H, ALQUILO C1-6, CICLOALQUILO C3-8, FENILO, ENTRE OTROS L1 ES METILENO, ETILENO, ETENILENO O ACETILENO DONDE CADA ATOMO DE CARBONO EN METILENO O ETILENO ESTA OPCIONALMENTE SUSTITUIDO POR 1 O 2 RADICALES SELECCIONADOS ENTRE HIDROXI, HALOGENO, ENTRE OTROS L2 ES METILENO O ETILENO EN LOS QUE CADA ATOMO DE CARBONO ESTA OPCIONALMENTE SUSTITUIDO POR 1 O 2 RADICALES SELECCIONADOS ENTRE HIDROXI, HALOGENO, ENTRE OTROS L3 ES -CH=CH-, -C(O)-, ENTRE OTROS R1 Y R2 SON INDEPENDIENTEMENTE H
