Refers to a compound of formula (i) wherein: Het is Preferred dimetilfuran - 2.2 - 3 (2H) - One X is selected from aryl or heteroaryl optionally replaced where the substituents are selected from c1-4 alkyl, cycloalkyl c3-6, c1-4 alkoxy, CF3, among others Z Select between Piri DIN thiocyanatoacetate, imidazo [1,2-a] pyridin-3 thiocyanatoacetate, imidazo [1,2-b] pyridazin-3 2 - ILO and imidazo [1,2 - B] pyridazin-3 6-yl each optionally replaced c1-4 alkyl R2 is optionally substituted by Fluorine R2 or two groups taken together the carbon Atom to which they are United to form a cycloalkyl Ring C3.Preferred compounds are: 4 - (4-hydroxyphenyl) - 5 - (4-methoxyphenyl) - 2,2 - dimetilfuran - 3 (2H) - One 5 - (4-hydroxyphenyl) - 2,2-dimethyl - 4 - (pyridin-4-yl) furan - 3 (2H) - 4 - (ona 3 - (4-hydroxyphenyl) - 5,5 - dimethyl - 2 - oxo - 4.5 - dihydrofuran-2 - il) benzonitrile among others. In addition to such a Pharmaceutical composition.This Compound is an inhibitor of phosphodiesterase 10 (PDE10) useful in the treatment of disorders of the central nervous systemSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: HET ES DE PREFERENCIA 2,2-DIMETILFURAN-3(2H)-ONA X SE SELECCIONA ENTRE ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO DONDE LOS SUSTITUYENTES SE SELECCIONAN ENTRE ALQUILO C1-4, CICLOALQUILO C3-6, ALCOXI C1-4,CF3, ENTRE OTROS Z SE SELECCIONA ENTRE PIRIDIN-2-ILO, IMIDAZO[1,2-a]PIRIDIN-2-ILO, IMIDAZO[1,2-b]PIRIDAZIN-2-ILO E IMIDAZO[1,2-b]PIRIDAZIN-6-ILO CADA UNO OPCIONALMENTE SUSTITUIDO R2 ES ALQUILO C1-4 OPCIONALMENTE SUSTITUIDO POR FLUOR O DOS GRUPOS R2 TOMADO JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN ANILLO CICLOALQUILO C3. SON COMPUESTOS PREFERIDOS: 4-(4-HIDROXIFENIL)-5-(4-METOXIFENIL)-2,2-DIMETILFURAN-3(2H)-ONA 5-(4-HIDROXIFENIL)-2,2-DIMETIL-4-(PIRIDIN-4-IL)FURAN-3(2H)-ONA 4-(3-(4-HIDROXIFENIL)-5,5-DIMETIL-4-OXO-4,5-DIHIDROFURAN-2-IL) BENZONITRILO ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE FOSFODIEST
