STANGELAND, ERIC L.,PATTERSON, LORI JEAN,ZIPFEL, SHEILA
申请号：
ES11714878
公开号：
ES2543064T3
申请日:
2011.03.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** in which: X is -CH- or -N-； HAr is selected from 2-pyridyl, 3-pyridyl, 4-pyridyl, 5-pyridyl, 2-furyl, 4-furyl, 2- thienyl, 3-thienyl, and 4-thienyl； a is 0 or 1； R1 is halo or trifluoromethyl； and R2-6 are independently hydrogen, halo, C1-6 alkyl, -CF3, C2-6 alkynyl, -O-C1-6 alkyl, -OCF3, C1-4 alkylene-O-C1-4 alkyl, C0-1 alkylene -phenyl, -C0-3 alkyl-phenyl-C0-6-OH alkylene, -CN, -COOH, -CHO, -C (O) -C 1-6 alkyl, -C (O) O-C1-4 alkyl, -CH2SH, -C1-6 alkyl, C1-4-S-C1-4 alkyl or -NO2； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula I:**Fórmula** en la que: X es -CH- o -N-； HAr es seleccionado de 2-piridilo, 3-piridilo, 4-piridilo, 5-piridilo, 2-furilo, 4-furilo, 2- tienilo, 3-tienilo, y 4-tienilo； a es 0 o 1； R1 es halo o trifluorometilo； y R2-6 son independientemente hidrógeno, halo, alquilo C1-6, -CF3, alquinilo C2-6, -O-alquilo C1-6, -OCF3, alquileno C1-4-O-alquilo C1-4, alquilen C0-1-fenilo, -Oalquilen C0-3-fenilo -alquilen C0-6-OH, -CN, -COOH, -CHO, -C(O)-alquilo C1-6, -C(O)O-alquilo C1-4, -CH2SH, -Salquilo C1-6, alquilen C1-4-S-alquilo C1-4 o -NO2； o una sal farmacéuticamente aceptable del mismo.
