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Nicotinamides substituted as modulators of KCNQ2 / 3
专利权人:
Grünenthal GmbH
发明人:
KÜHNERT, Sven,MERLA, Beatrix,BAHRENBERG, Gregor,SCHRÖDER, Wolfgang
申请号:
ES10708139
公开号:
ES2556772T3
申请日:
2010.03.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Substituted nicotinamides of the general formula ** Formula ** A1 represents CR10R11o S; A2 represents CR12R13, C (>; = O) O, S, S (>; = O) 2; R1 represents (C1-10) alkyl or heteroalkyl (C2-10) in each case saturated or unsaturated, linear or branched, substituted simply or multiple or unsubstituted; cycloalkyl (C3-10) or tererocyclyl, in each case saturated or unsaturated, substituted simply or multiplely or unsubstituted; aryl or heteroaryl, in each case substituted simply or multiplely or unsubstituted; cycloalkyl (C3-10) or heterocyclyl linked through a (C1-8) alkyl or a heteroalkyl (C2-8), in each case saturated or unsaturated, substituted simply or multiple or unsubstituted, the alkyl chain being able to Hereroalkyl in each case be linear or branched, saturated or unsaturated, substituted simply or multiple or unsubstituted; or aryl or heteroaryl linked through a (C2-8) alkyl, in each case substituted in a simple or multiple or unsubstituted form, the alkyl or heteroalkyl chain being able in each case to be linear or branched, saturated or unsaturated, substituted so single or multiple or unsubstituted.Nicotinamidas sustituidas de fórmula general**Fórmula** A1 representa CR10R11o S; A2 representa CR12R13, C(>;=O) O, S, S(>;=O)2; R1 represnta alquilo (C1-10) o heteroalquilo (C2-10) en cada caso saturado o insaturado, lineal o ramificado, sustituido de forma simple o múltiple o no sustituido; cicloalquilo (C3-10) o tererociclilo, en cada caso saturado o insaturado, sustituido de forma simple o múltiple o no sustituido; arilo o heteroarilo, en cada caso sustituido de forma simple o múltiple o no sustituido; cicloalquilo (C3-10) o heterociclilo unido a través de un alquilo (C1-8) o un heteroalquilo (C2-8), en cada caso saturado o insaturado, sustituido de forma simple o múltiple o no sustituido, pudiendo la cadena alquilo o hereroalquilo en cada caso ser lineal o ramificada, saturada o no saturada, sustituida de forma simple o múltiple o no sistituida; o a
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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