MEDICAL RESEARCH COUNCIL TECHNOLOGY;GENENTECH INC.
发明人:
CHAN, BRYAN,CHEN, HUIFEN,ESTRADA, ANTHONY,SHORE, DANIEL,SWEENEY, ZACHARY,MCIVER, EDWARD
申请号：
CA2809557
公开号：
CA2809557A1
申请日:
2011.09.21
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula I, or pharmaceutically acceptable salts or esters thereof, (Formula I) wherein R1 is selected from: aryl； heteroaryl； -NHR3； fused aryl-C4_7-heterocycloalkyl； -CONR4R5； - NHCOR6； -C3-7-cycloalkyl,-NR3R6； -OR3； OH； NR4R5； and alkyl optionally substituted with a substituent selected from R11 and a group A； wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7- heterocycloalkyi are each optionally substituted with one or more substituents selected from C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, aryl and a group A, and said C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, and aryl substituents are in turn each optionally substituted with one or more groups selected from R11 and a group A； R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, heterocycloalkyi, fused aryl-C4-7-rheterocycloalkyl and halogen, wherein said C1-6-alkyl, C2-6-alkenyl, aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted with one or more substituents selected from R11 and A. Further aspects relate to pharmaceutical compositions and therapeutic uses of said compounds.
