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Octahydro-cyclobuta [1,2-c； 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
- 专利权人:
- F. Hoffmann-La Roche AG
- 发明人:
- MATTEI, Patrizio,HUNZIKER, Daniel,DI GIORGIO, Patrick,HERT, Jérôme,RUDOLPH, Markus,WANG, Lisha
- 申请号：
- ES14805527
- 公开号：
- ES2656198T3
- 申请日:
- 2014.11.24
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- Compounds of formula (I) ** (See formula) ** wherein R1 is substituted quinolinyl, substituted 1,2,3,4-tetrahydroquinolinyl, substituted isoquinolinyl, substituted 1,2,3,4-tetrahydroisoquinolinyl, 9H-carbazolyl substituted, substituted chromanyl, substituted indolyl, substituted naphthyl, substituted oxazolyl, substituted phenyl, substituted phenyl-C1-C7 alkyl, substituted phenyl-C3-C8 alkyl, substituted phenoxy-C1-C7 alkyl, phenyl-C1-alkoxy Substituted C7, substituted phenyl-C2-C7-alkenyl, substituted phenylalkyl, substituted pyridacinyl, substituted pyridacinyl-C1-C7-substituted alkyl, pyridacinyl-C2-C7-substituted alkynyl, substituted pyridinyl, substituted C1-C7-substituted pyridinyl , substituted pyridinyl-C2-C7-alkenyl, substituted pyridinyl-alkynyl, substituted pyridinonyl, substituted pyridinonyl-C1-C7-substituted alkyl, pyridinonyl-C2-C7-substituted alkynyl, substituted thiophenyl-substituted-thiophenyl-C1-alkyl alkenyl -C2-C7 substituted, substituted tetralinyl or substituted tetralinonyl, wherein substituted quinolinyl, substituted 1,2,3,4-tetrahydroquinolinyl, substituted isoquinolinyl, substituted 1,2,3,4-tetrahydroisoquinolinyl, substituted 9H-carbazolyl, substituted chromanyl , substituted indolyl, substituted naphthyl, substituted oxazolyl, substituted phenyl, substituted phenyl-C1-C7-alkyl, substituted phenyl-cycloalkyl-C3-C8, substituted phenoxy-C1-C7-alkyl, phenylalkenyl - substituted C2-C7, substituted phenylalkyl, substituted pyridacinyl, substituted pyridacinyl-C1-C7-alkyl, substituted pyridacinylalkyl-C2-C7, substituted pyridacinylalkyl-alkyl, substituted pyridinyl, pyridinyl-C1-C7-alkyl-substituted-C2-C7 substituted pyridinylalkyl, substituted pyridinonyl, substituted pyridinonyl-C1-C7-alkyl, substituted pyridinonyl-alkenyl-C2-C7, substituted pyridinonyl-alkynyl, substituted thiophenyl, thiophenyl-C1-C7-substituted alkyl, thiophenylalkenyl-C2-C7 substituted, thiophenylalkyl substituted, tetralinyl substituted and tetralinonyl substituted are
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
