MCIVER, EDWARD GILES,SMILJANIC, ELA,HARDING, DENISE JAMILLA,HOUGH, JOANNE
申请号：
CA2754605
公开号：
CA2754605C
申请日:
2010.03.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A compound of formula (I), or a pharmaceutically acceptable salt or esterthereof, wherein R1 is selected from:aryl； heteroaryl； -NHR3； fused aryl-C4-7-heterocycloalkyl； -CONR4R5； -NHCOR6； -C3-7-cycloalkyl； -O-C3-7-cycloalkyl； -NR3R6；and optionally substituted -C1-6 alkyl； wherein said aryl, heteroaryl, fusedaryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl areeach optionally substituted； R2 is selected from hydrogen, aryl, C1-6-alkyl,C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7 heterocy-cloalkyland halogen, wherein said c1-6-alkyl, C2-6-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substitut-ed.Further aspects relate to pharmaceutical compositions, therapeutic uses andprocess for preparing compounds of formula (I).
