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Chromenone analogues as sirtuin modulators
专利权人:
GLAXOSMITHKLINE LLC
发明人:
OALMANN, CHRISTOPHER,PERNI, ROBERT B.,VU, CHI B.
申请号:
ES09817054
公开号:
ES2511942T3
申请日:
2009.09.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of the formula (II): ** Formula ** or a salt thereof, wherein: each R20 is independently selected from hydrogen, halo, -C≡N, fluoro-substituted C1-C2 alkyl, -O-alkyl C1-C2 fluoro-substituted, -S-C1-C2 alkyl fluoro-substituted, C1-C4 alkyl, -S-C1-C4 alkyl, C3-C7 cycloalkyl, (C1-C2) alkyl -N (R13) (R13) , -O-CH2CH (OH) CH2OH, -O-(C1-C3) alkyl -N (R13) (R13), and -N (R13) (R13); R11 is selected from a carbocycle and a heterocycle, wherein R11 is optionally substituted with one to two substituents independently selected from halo, -C≡N, C1-C4 alkyl,>; = O, C3-C7 cycloalkyl, C1-C4 alkyl fluoro -replaced, -O-R13, -S-R13, -alkyl (C1-C4) -N (R13) (R13), -N (R13) (R13), -O-alkyl (C1-C4) -N ( R13) (R13), -alkyl (C1-C4) -O-alkyl (C1-C4) -N (R13) (R13), -C (O) -N (R13) (R13), and -alkyl (C1 -C4) -C (O) -N (R13) (R13), and when R11 is phenyl, R11 is also optionally substituted with 3,4-methylenedioxy, 3,4-methylenedioxy fluoro-substituted, 3,4-ethylenedioxy, or 3,4-ethylenedioxy fluoro-substituted, O- (saturated heterocycle), O- (saturated heterocycle) fluoro-substituted, or O- (saturated heterocycle) fluoro-substituted substituted with C1-C4 alkyl, wherein each R13 is selected independently of hydrogen and C1-C4 alkyl; or two R13 are taken together with the nitrogen atom to which they are attached to form a 4- to 8-membered saturated heterocycle, optionally comprising an additional heteroatomic unit selected from NH, S, S (>; = O), S (>; = O) 2, and O, where when R13 is alkyl, the alkyl is optionally substituted with one or more substituents selected from -OH, fluoro, -NH2, -NH-C1-C4 alkyl, -N- (C1-C4 alkyl ) 2, -NH (CH2CH2OCH3), and -N (CH2CH2OCH3) 2 and when two R13 are taken together with the nitrogen atom to which they are linked to form a 4 to 8-membered saturated heterocycle, the saturated heterocycle is optionally substituted with to any carbon atom with -OH, C1-C4 alkyl, fluoro, -NH2, -NH-C1-C4 alkyl, -N- (C1-C4 alkyl) 2, -NH (CH2CH2OCH3), or -N (CH2CH2
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