The present invention provides a pharmaceutical composition being an exellent prophylactic or therapeutic drug for the diseases relating with immunization such as autoimmune diseases etc.A pharmaceutical composition containing the one selected from a group consisting 1or more than 2 of a P P A R modulator, and a compound selected from a group consisting 1 or more than 2 of an amino alcohol derivative of the following fomula (I):[wherein, R1and R2maybe the same or different, each represents a hydrogen atom etc., R3represents a C1-6 alkyl group or a hydroxymethyl group, R4represents a hydrogen atom, a C1-6 alkyl group etc., R5represents a phenyl group 1~3 substituted by a group selected from a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group etc., X represents a vinylene group ( C H=C H group) , an oxygen atom, etc., Y represents a single bond, an oxygen atom etc., Z represents a single bond, a C1-8 alkylene group etc., n represents an integer of 2 or 3] and the pharmaceutically acceptable salt thereof.提供作為與自體免疫疾病等免疫作用關連之疾病之預防或治療藥優異之醫藥組成物。一種醫藥組成物,含有由PPAR調節劑而成之群選出之1或2以上,與由如下式(I)胺醇衍生物及或其藥理學容許鹽而成之群選出之1或2以上[式中,R1及R2相同或相異為氫原子等,R3為C1-C6烷基或羥甲基,R4為氫原子、C1-C6烷基等,R5為由氫原子、鹵素原子、氰基、C1-C6烷基等而成之群選出之基1~3個取代之苯基,X為伸乙烯基(CH=CH基)、氧原子等,Y為單鍵、氧原子等,Z為單鍵、C1-C8伸烷基等,n為2或3之整數]。
