VU, CHI,OALMANN, CHRISTOPHER,PERNI, ROBERT,WHITE, BRIAN
申请号：
ES09817056
公开号：
ES2517690T3
申请日:
2009.09.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having a structure of the structural formula (II): ** Formula ** or a salt thereof, wherein: each of Z1, Z2 and Z3 is independently selected from N and C (R9), wherein: no more than one of Z1, Z2 and Z3 is N； each R9 is independently selected from hydrogen, halo, -CN, fluoro-substituted C1-C2 alkyl, -O-fluoro-substituted C1-C2 alkyl, -S-C1-C2 alkyl-substituted with fluoro, C1-C4 alkyl, - S-C1-C4 alkyl, C3-C7 cycloalkyl, (C1-C2) alkyl -N (R13) (R13), -O-CH2CH (OH) CH2OH, -O-(C1-C3) alkyl -N (R13) (R13) and -N (R13) (R13)； and ---- represents an optional link, W1 is selected from -NH- or -N>； =, and W2R14 is selected from -NR14- and -CR14>； =, so that when W2 (R14) is -C ( R14)>； =, W2 is linked to C (R12) through a double bond, where when W1 is -NH-, W2 (R14) is -CR14>； =； and when W1 is -N>； = linked to C (R12) through a double bond, W2 (R14) is -NR14-； R11 is selected from a carbocycle and a heterocycle, wherein R11 is optionally substituted with one to two substituents independently selected from halo, -CN, C1-C4 alkyl,>； = O, C3-C7 cycloalkyl, C1-C4 alkyl substituted with fluoro , -O-R13, -S-R13, (C1-C4) alkyl -N (R13) (R13), -N (R13) (R13), -O-alkyl (C1-C4) -N (R13) ( R13), (C1-C4) -O-alkyl (C1-C4) -N (R13) (R13), -C (O) -N (R13) (R13) and (C1-C4) -C ( O) -N (R13) (R13), and when R11 is phenyl, R11 is also optionally substituted with 3,4-methylenedioxy, 3,4-methylenedioxy substituted with fluoro, 3,4-ethylenedioxy, 3,4-ethylenedioxy substituted with fluoro, O- (saturated heterocycle), O- (saturated heterocycle) substituted with fluoro, O- (saturated heterocycle) substituted with C1-C4 alkyl, wherein each R13 is independently selected from hydrogen and C1-C4 alkyl； or two R13 are taken together with the nitrogen atom to which they are attached to form a 4- to 8-membered saturated heterocycle, optionally comprising an additional heteroatom selected from N (R13), S, S (>； = O), S ( >； = O) 2 and O, where: when R13 is alkyl, the alkyl is o
