Derived from 8 - [6 - [3 - (amino) proposxi] - 3-pyridyl) 1-isopropylamide [4,5-c] quinoline-2-ona, it is a selective modulator of induced electrocardiographic enzyme (ATM) for the treatment of cancer
BARLAAM, Bernard Christophe,PIKE, Kurt Gordon,HUNT, Thomas Anthony,EATHERTON, Andrew John
申请号：
PE2018000343
公开号：
PE20181078A1
申请日:
2016.09.15
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The derivative of the invention is 8 - [6 - [3 - (amino) propxi] - 3-pyridyl-1-isopropylamide [4,5-c] quinoline-2-ona (I) or a formula salt with acceptable efficacy, wherein R1 is methyl； R2 is hydrogen or methyl； R3 is hydrogen or fluorine； R4 is hydrogen or methyl； R5 is hydrogen or fluorine. The preferred compounds are: 8 - [6 - [3 - (dimethylamine) proposxi] - 3-pyridine-3-methylpyridine-3 [4, 5-c] quinolin-2-ona； 7-fluoro-1-isopropyl-3-methyl-8 - [6 - [3 - (1-piperidil) proposxi] - 3-pyridine-3 [4, 5-c] quinolin-2-ona. The present invention is useful for the treatment of cancer. These compounds selectively regulate the mutant ATM resonance enzyme.La presente invencion refiere un derivado de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona de formula (I) o una sal farmaceuticamente aceptable de este, donde R1 es metilo； R2 es hidro o metilo； R3 es hidro o fluoro； R4 es hidro o metilo； y R5 es hidro o fluoro. Son compuestos preferidos: 8-[6-[3-(dimetilamino)propoxi]-3-piridil]-7-fluoro-1-isopropil-3-metilimidazo[4,5-c]quinolin-2-ona； 7-fluoro-1-isopropil-3-metil-8-[6-[3-(1-piperidil)propoxi]-3-piridil]imidazo[4,5-c]quinolin-2-ona； entre otros. La presente invencion es util para el tratamiento del cancer. Estos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM).
