BARLAAM, Bernard Christophe,HUNT, Thomas Anthony,EATHERTON, Andrew John,PIKE, Kurt Gordon
申请号：
PE0006122018
公开号：
PE13452018A1
申请日:
2016.11.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Relating to compounds imidazo [4,5-c] quinolin-2 - one of formula (i), wherein R1 is Methyl or Hydro R2 is Methyl, X is 1 or 2 R3 is C4 C6 cycloalkyl optionally substituted with a methoxy Group.Isopropyl, among others R4 and R5 is Hydro or Methyl is Hydro or Fluorine. It also relates to pharmaceutical compositions containing same and preparation methods.These compounds selectively modulate kinase ataxia telangiectasia mutated (ATM), which are useful for treating or Preventing a disease mediated by ATM, including cancer.Referido a compuestos imidazo[4,5-c]quinolin-2-ona de formula (I), donde R1 es metilo R2 es hidro o metilo X es 1 o 2 R3 es cicloalquilo C4-C6 opcionalmente sustituido con un grupo metoxi, isopropilo, entre otros R4 es hidro o metilo y R5 es hidro o fluor. Tambien se refiere a composiciones farmaceuticas que los comprenden y metodos de preparacion. Dichos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM), por lo que son utiles para tratar o prevenir una enfermedad mediada por ATM, incluido el cancer.
