BARLAAM, Bernard Christophe,HUNT, Thomas Anthony,EATHERTON, Andrew John,PIKE, Kurt Gordon
申请号：
PE0006102018
公开号：
PE13462018A1
申请日:
2016.11.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Relating to compounds imidazo [4,5-c] quinolin-2 - one of formula (i), wherein R1 is azetidinilo, pirrolidinilo, among others R2 is Methyl, cicloalquiloc4 - C6Among others R3 is Methyl or R4 is Hydro and Hydro or fluoride. It also relates to pharmaceutical compositions containing same and its pharmaceutically acceptable Salts.These compounds selectively modulate kinase ataxia telangiectasia mutated (ATM) and are useful for treating or Preventing a disease mediated by ATM, including cancer.Referida a compuestos imidazo[4,5-c]quinolin-2-ona de formula (I), donde R1 es azetidinilo, pirrolidinilo, entre otros R2 es isopropilo, cicloalquiloC4-C6, entre otros R3 es hidro o metilo y R4 es hidro o fluor. Tambien se refiere a composiciones farmaceuticas que los comprenden y sus sales farmaceuticamente aceptables. Dichos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM) y son utiles para tratar o prevenir una enfermedad mediada por ATM, incluido el cancer.
