BARLAAM, Bernard Christophe,HUNT, Thomas Anthony,EATHERTON, Andrew John,PIKE, Kurt Gordon
申请号：
PE2018000612
公开号：
PE20181345A1
申请日:
2016.11.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to the pyridan compound [4,5-c] quinine-2-ona (I),Among them, R1 is methyl； R2 is hydrogen or methyl； X is 1 or 2； R3 is optional cyclopentyl compound C4-C6, which is replaced by a methoxi, isopropyl and other substances； R4 is hydrogen or methyl； R5 is hydrogen or fluorine. It also refers to their pharmacology composers and preparation methods. These compounds selectively regulate the mutant electroplate resonance enzyme (ATM),Therefore, they are useful for the treatment or prevention of diseases in the atmosphere, including cancer.Referido a compuestos imidazo[4,5-c]quinolin-2-ona de formula (I), donde R1 es metilo； R2 es hidro o metilo； X es 1 o 2； R3 es cicloalquilo C4-C6 opcionalmente sustituido con un grupo metoxi, isopropilo, entre otros； R4 es hidro o metilo； y R5 es hidro o fluor. Tambien se refiere a composiciones farmaceuticas que los comprenden y metodos de preparacion. Dichos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM), por lo que son utiles para tratar o prevenir una enfermedad mediada por ATM, incluido el cancer.
