From 8 - [6 - [3 - (amino) propoxy] - 1 - isopropilimidazo 3-pyridyl] [4,5-c] quinolin-2 - ona as modulators Selective kinase ataxia telangiectasia mutated (ATM) for the treatment of cancer
BARLAAM, Bernard Christophe,PIKE, Kurt Gordon,HUNT, Thomas Anthony,EATHERTON, Andrew John
申请号：
PE0003432018
公开号：
PE10782018A1
申请日:
2016.09.15
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The present Invention relates to a Derivative of 8 - [6 - [3 - (amino) propoxy] - 1 - isopropilimidazo 3-pyridyl] [4,5-c] quinolin-2 - ona formula (i) or a pharmaceutically acceptable Salt,Where R1 is Methyl R2 or R3 is Methyl is Hydro, Hydro or fluoro R4 and R5 is Hydro or Methyl or is Hydro fluoro.Preferred compounds are: 8 - [6 - [3 - (dimethylamino) propoxy] - 3 - pyridyl) - 7 - fluoro - 1 - isopropyl - 3 - metilimidazo [45 - C] quinolin-2 - One 7 - fluoro - isopropyl - 3 - methyl - 1 - 8 - [6 - [3 - (1 - 2-piperidyl) propoxy] - 3-pyridyl] imidazo [4,5-c] quinolin-2 - One among others. The Invention is useful for the treatment of cancer.These compounds selectively modulate kinase ataxia telangiectasia mutated (ATM).La presente invencion refiere un derivado de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona de formula (I) o una sal farmaceuticamente aceptable de este, donde R1 es metilo R2 es hidro o metilo R3 es hidro o fluoro R4 es hidro o metilo y R5 es hidro o fluoro. Son compuestos preferidos: 8-[6-[3-(dimetilamino)propoxi]-3-piridil]-7-fluoro-1-isopropil-3-metilimidazo[4,5-c]quinolin-2-ona 7-fluoro-1-isopropil-3-metil-8-[6-[3-(1-piperidil)propoxi]-3-piridil]imidazo[4,5-c]quinolin-2-ona entre otros. La presente invencion es util para el tratamiento del cancer. Estos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM).
