BARLAAM, Bernard Christophe,HUNT, Thomas Anthony,EATHERTON, Andrew John,PIKE, Kurt Gordon
申请号：
PE2018000610
公开号：
PE20181346A1
申请日:
2016.11.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
About the pyridane compound [4,5-c] quinine-2-ona (I),R1 is Azerbaijani, pyridine, etc.； R2 is isopropyl, cyclopentyl-c6, etc.； R3 is hydrogen or methyl； R4 is hydrogen or fluorine. It also refers to the inclusion of their pharmacology composers and their pharmacologically acceptable salts. These compounds selectively modulate the belts of mutated electrolysis (ATM) disorders that can be used to treat or prevent atmospheric vector diseases, including cancer.Referida a compuestos imidazo[4,5-c]quinolin-2-ona de formula (I), donde R1 es azetidinilo, pirrolidinilo, entre otros； R2 es isopropilo, cicloalquiloC4-C6, entre otros； R3 es hidro o metilo y R4 es hidro o fluor. Tambien se refiere a composiciones farmaceuticas que los comprenden y sus sales farmaceuticamente aceptables. Dichos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM) y son utiles para tratar o prevenir una enfermedad mediada por ATM, incluido el cancer.
