benzoic acid, benzoic acid derivatives and hydrocodone heteroaryl carboxylic acid conjugates, prodrugs, methods of production and use of these

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专利权人:

INC.;KEMPHARM

发明人:

ANDREA K. MARTIN,BINDU BERA,CHRISTAL MICKLE,GUOCHEN CHI,JAROSLAW KANSKI,SVEN GUENTHER,TRAVIS MICKLE

申请号：

BR112012000569

公开号：

BR112012000569A2

申请日:

2010.07.01

申请国别(地区):

BR

年份:

2015

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

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中国工程科技知识中心

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http://www.ckcest.cn/home/