MICKLE TRAVIS U S A,GUENTHER SVEN U S A,MICKLE CHRISTAL U S A,CHI GUOCHEN U S A,KANSKI JAROSLAW U S A,MARTIN ANDREA K U S A,BERA BINDU U S A
申请号：
IN10011/DELNP/2011
公开号：
IN2011DN10011A
申请日:
2011.12.19
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
