Travis Mickle,Sven Guenther,Christal Mickle,Guochen Chi,Jaroslaw Kanski,Andrea K. Martin,Bindu Bera
申请号：
US15076586
公开号：
US09650387B2
申请日:
2016.03.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
