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Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof
专利权人:
Inc.;KemPharm
发明人:
Travis Mickle,Sven Guenther,Christal Mickle,Guochen Chi,Jaroslaw Kanski,Andrea K. Martin,Bindu Bera
申请号:
US15076586
公开号:
US09650387B2
申请日:
2016.03.21
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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