BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF

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专利权人:

INC.;KEMPHARM

发明人:

MICKLE, TRAVIS,GUENTHER, SVEN,MICKLE, CHRISTAL,CHI, GUOCHEN,KANSKI, JAROSLAW,MARTIN, ANDREA K.,BERA, BINDU

申请号：

SG2011097482

公开号：

SG177445A1

申请日:

2010.07.01

申请国别(地区):

SG

年份:

2012

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

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