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NOUVEAU DERIVE 3-AZABICYCLO[3.1.0]HEXANE ET SON UTILISATION A DES FINS MEDICALES
专利权人:
UBE INDUSTRIES, LTD.;SANWA KAGAKU KENKYUSHO CO., LTD.
发明人:
TANIKO KAORI,MIYAZAWA TOSHIYUKI,KANEKO TATSUROH,KURUMAZUKA DAISUKE,HARADA SATOKO,IZUCHI TORU,OKABE MORIO,IWAMURA, RYO,TSUZAKI, YASUNORI,SETOGUCHI, HIROYUKI,IMURA, YUUKI,AKAZA, HIROTO,SHIMIZU, MOTOHISA
申请号:
CA2927527
公开号:
CA2927527A1
申请日:
2014.11.19
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention addresses the problem of providing a compound which has few adverse side effects, high safety and an antagonistic activity to a µ opioid receptor. A compound represented by general formula (I) [wherein R1 and R2 may be the same as or different from each other and independently represent a hydrogen atom or a halogen atom (wherein a case in which each of R1 and R2 represents a halogen atom is excluded); R3 represents a C1-C3 alkyl group or a vinyl group; and R4 represents formula (II) (wherein R5 represents a hydroxy group or a C1-C3 alkoxy group; and R6 and R7 may be the same as or different from each other and independently represent a hydrogen atom or a halogen atom) or formula (III) (wherein the ring A represents a C5-C7 cycloalkyl group which may be substituted by a C1-C3 alkoxy group and is substituted by a halogen atom or a 5- to 7-membered saturated heterocyclic group which is substituted by a halogen atom)] or a pharmacologically acceptable salt thereof.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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