ISOXAZOLE DERIVATIVE AS MUTANT ISOCITRATE DEHYDROGENASE 1 INHIBITOR

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专利权人:

LIMITED;NATIONAL CANCER CENTER;DAIICHI SANKYO COMPANY;DAIICHI SANKYO COMPANY, LIMITED

发明人:

SAITO SHOICHI,ITOH MASAO,FUJISAWA TETSUNORI,SAITO HIRONAO,KIYOTSUKA YOHEI,WATANABE HIDEAKI,MATSUNAGA HIRONORI,KAGOSHIMA YOSHIKO,SUZUKI TETSUYA,OGAWARA YOKO,KITABAYASHI KAZUO

申请号：

SG11201702389X

公开号：

SG11201702389XA

申请日:

2015.10.01

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R 1 , R 2 , R 3 , Y, and Z are as defined in claim 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/