KIM YO HAN,PARK JAE HYUN,WOO JONG SOO,KIM YONG IL,KIM KYEONG SOO,KIM JIN CHEUL
申请号：
NZ61960612
公开号：
NZ619606A
申请日:
2012.05.18
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein is a pharmaceutical composition comprising an amide derivative of the compound of formula I, known as poziotinib (1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one) or a pharmaceutically acceptable salt thereof and a non-metallic salt lubricant. The presence of the non-metallic salt lubricant prevents the formuation of the dimer impurity which reduces the activity of the compound of formula I in the treatment of cancer as a cell-growth inhibitor.
