It refers to a compound derived from dihydropyrimidin-2-one of formula (I) or one of its pharmaceutically acceptable salts, where: R1 is C4-C8 alkyl, C3-C8 alkyl substituted by hydroxy, among others； R2 is halogen, C1-C6 alkyl, among others； R3 -Yb-COO-R30, C1-C6 alkyl, among others n is an integer from 0 to 3； among others； R4 is H, or methyl； R5 is -Yc-COO-R50, H, among others； R6 is methyl； Yc is optionally substituted C1-C6 alkenylene, CH2-CH2-O-CH2, among others； Yb is C1-C6 alkenylene, C3-C6 cycloalkylene, among others； R30 is H or C1-C4 alkyl；Is R50 h or C1-C4 The most popular compounds are: acid 3 - (s) - 4 - [3-chloro-4 - (3,3-dimethyl-butyl) - phenyl] - 5-isopropyl-4-methyl-2-oxo-3, 4-dihydro-2h-pirimidin-1-il} - PROPADINE； acid 4 - {5-ter-butil-4 - [3-chloro-4 - (2-dimethyl-probxi) phenyl] - 2, 4-pyr-methyl； others You also mean a composer The compound is an inhibitor of the huerfah gamma receptor associated with the retina,It is very useful in the treatment of rheumatoid arthritis, psychosis, etcSe refiere a un compuesto derivado de dihidropirimidin-2-ona de formula (I) o una de sus sales farmaceuticamente aceptables, donde: R1 es alquilo C4-C8, alquilo C3-C8 sustituido con hidroxi, entre otros； R2 es halogeno, alquilo C1-C6, entre otros； R3 -Yb-COO-R30, alquilo C1-C6, entre otros n es un numero entero de 0 a 3； entre otros； R4 es H, o metilo； R5 es -Yc-COO-R50, H, entre otros； R6 es metilo； Yc es alquenileno C1-C6 opcionalmente sustituido, CH2-CH2-O-CH2, entre otros； Yb es alquenileno C1-C6, cicloalquileno C3-C6, entre otros； R30 es H o alquilo C1-C4； R50 es H o alquilo C1-C4. Entre los compuestos preferidos tenemos: Acido 3-{(S)-4-[3-cloro-4-(3,3-dimetil-butil)-fenil]-5-isopropil-4-metil-2-oxo-3,4-dihidro-2H-pirimidin-1-il}-propionico； acido 4-{5-ter-butil-4-[3-cloro-4-(2,2-dimetilpropoxi)fenil]-2-oxo-3,4-dihidro-2H-pirimidin-1-il}-butanoico； entre otros. Tambien se refiere a una composicion. Dicho compuesto es un inhibidor del receptor gamma huerfano
