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1'-substituted carbanucleoside prodrugs for antiviral treatment
专利权人:
INC.;GILEAD SCIENCES
发明人:
CHO, AESOP,KIM, CHOUNG,RAY, ADRIAN,ZHANG, LIJUN
申请号:
ES11725838
公开号:
ES2465265T3
申请日:
2011.05.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula I: Formula I or a pharmaceutically acceptable salt or ester thereof; wherein R1 is H, C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl; R2 is OH or -OC (O) R3; each R3 is independently H, OR4, NH (R4), N (R4) 2, SR4, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C4-C8 carbocyclyl, C1-C8 arylalkyl , C1-C8 heterocyclylalkyl, aryl, heterocyclyl or heteroaryl; each Ra, R4 or R6 is independently C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C3-C8 carbocyclyl, C1-C8 arylalkyl, C1-C8 heterocyclyl, C6-C20 heterocyclyl -C20 or heteroaryl; one of W1 or W2 is and the other of W1 or W2 is OR4 orUn compuesto de fórmula I: Fórmula I o una sal o éster farmacéuticamente aceptable del mismo; en la que R1 es H, alquilo C1-C8, alquenilo C2-C8 o alquinilo C2-C8; R2 es OH u -OC(O)R3; cada R3 es independientemente H, OR4, NH(R4), N(R4)2, SR4, alquilo C1-C8, alquenilo C2-C8, alquinilo C2-C8, carbociclilo C3-C8, carbociclilalquilo C4-C8, arilalquilo C1-C8, heterociclilalquilo C1-C8, arilo, heterociclilo o heteroarilo; cada Ra, R4 o R6 es independientemente alquilo C1-C8, alquenilo C2-C8, alquinilo C2-C8, carbociclilo C3-C8, carbociclilalquilo C3-C8, arilalquilo C1-C8, heterociclilalquilo C1-C8, arilo C6-C20, heterociclilo C2-C20 o heteroarilo; uno de W1 o W2 es y el otro de W1 o W2 es OR4 o
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