BRANDL, TRIXI,RAMAN, PRAKASH,RIGOLLIER, PASCAL,SEEPERSAUD, MOHINDRA,SIMIC, OLIVER
申请号：
PE0017742011
公开号：
PE05572012A1
申请日:
2010.04.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a Heterocyclic Compound of formula (i), where r is alkyl of C1 - C6, alquenilo C2 - C3 - C7 C6 alkyl or cycloalkyl C0 - C4 R is H, alkyl of C1 - C6, among others R1 and R2 are h, c1-c6 alkyl, alkoxyl C1 - C6, between other alkyl R4 is C1 - C3 - C8 C8, cycloalkyl, among others J is a link or A residue formula divalent NR6 - ch (R5) - C (= o) - R5 is C1 - C3 C8 alkyl, cycloalkyl - C8Among others, R6 H or c1-c4 alkyl g is a group of Formula - and - R7 and is a Link, CH2, C (or S), (OR) 2, among others R7 is c1-c6 alkyl, alkoxyl haloalquilo C1 - C6 C1 - C6, among others.Preferred compounds are: (5R, 8S) - 7 - [(2S) - 2 - [(2S) - 2 - (Cyclohexyl - 2 - {[(2R) - 1 - Ethyl pyrrolidin-2-one IL - carbonyl] amino} -) acetyl] - 3,3 - Dimethyl amino} - - butanoil] - 10:10 - dimethyl - n {- (1R, 2S) - 1 - [(pyrrolidin-1-yl - sulfonyl) Carbamoyl] - 2 - Vinyl - cyclopropyl} - 7 - - - aza spiro [3.0.4.1] - Deccan - 8 - carboxamide (5R, 8S) - 7 - [(2S) - 2 - [(2S) - 2 - (1 - {[2 - Tert Butyl - azetidin - il) carbonyl] amino} - 2 - acetyl cyclohexyl] amino} - 3.3 - dimethyl butanoil] - 10:10 - dimethyl - n {- (1R, 2S) - 1 - [(pyrrolidin-1-yl - sulfonyl) Carbamoyl] - 2 - Vinyl - cyclopropyl} - 7 - aza - Di - - [] - 3.0.4.1 Spiro decan - 8 - carboxamide, among others. These compounds are inhibitors of NS3 \/ 4a protease of hepatitis C virusREFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE R ES ALQUILO C1-C6, ALQUENILO C2-C6 O CICLOALQUILO C3-C7-ALQUILO C0-C4 R ES H, ALQUILO C1-C6, ENTRE OTROS R1 Y R2 SON H, ALQUILO C1-C6, ALCOXILO C1-C6, ENTRE OTROS R4 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS J ES UN ENLACE O UN RESIDUO DIVALENTE DE FORMULA -NR6-CH(R5)-C(=O)- R5 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS R6 ES H O ALQUILO C1-C4 G ES UN GRUPO DE FORMULA -E-R7 E ES UN ENLACE, CH2, C(O), S(O)2, ENTRE OTROS R7 ES ALQUILO C1-C6, HALOALQUILO C1-C6, ALCOXILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (5R,8S)-7-[(2S)-2-{[(2S)-2-CICLOHEXIL-2-({[(2R)-1-E
