The disclosure provides methods and uses for alleviating and/or treating pain including pain disorders using melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2； m is 0, 1 or 2； p is 0, 1, 2, 3, 4, 5, 6, 7 or 8； v is 2 or 3； A is aryl or heteroaryl； Z is 0, S or NR8； Y is chosen from hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is chosen from hydrogen, hydroxyl, -OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and -Z-(CH2)P-A； R1 is chosen from C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy- substituted C1-C4 alkyl, hydroxy-substituted C3-C6 cycloalkyl, and NHR5, wherein R5 is H, C1-C3 alkyl or C3-C6 cycloalkyl； R2 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen； R3 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl and halogen； R and R3 may be connected together to form an -0-(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system； R4 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen； R6 is chosen from hydrogen and C1-C4 alkyl； R7 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl and halogen； and R8 is chosen from hydrogen and C1-C4 alkyl.L'invention concerne des procédés et des utilisations qui permettent de soulager et/ou de traiter la douleur, y compris des troubles douloureux, à l'aide de ligands de type mélatonine de la formule 1 : ou de sels de qualité pharmaceutique de ceux-ci, dans ladite formule : n est 1 ou 2 ； m est 0, 1 ou 2 ； p est 0, 1, 2, 3, 4, 5, 6, 7 ou 8 ； v est 2 ou 3 ； A représente aryle ou hétéroaryle ； Z représente O, S ou NR8 ； Y est choisi parmi hydrogène, aryle ou hétéroaryle, alkyle en C1-C6, cycloalkyle en C3-C6 et R est choisi parmi hydrogène, hydroxyle, -OCF3, CF3, alkyle en C1-C8 , alkyloxy en C1-C8, alkylthio en C1-C8, halogène et -Z-(CH2)P-A ； R1 est choisi parmi alkyle e
