Refers to a compound dihydropyrimidine - 2 - One Derivative of formula (i) or a pharmaceutically acceptable salts thereof, where R1 is alkyl C8 alkyl C3 - C4, C8 substituted with Hydroxy, among others R2 is Halogen, alkyl of C1 - C6, among others R3 - YB - Coo - R30 C1 - C6 alkyl, N is a, among others Integer from 0 to 3 among others R4 or R5 is H, Methyl yc is - Coo - R50, h,Among others, R6 is Methyl yc is alquenileno C1 - C6 optionally substituted, - CH2 - or - CH2 CH2, among others and it is alquenileno cicloalquileno C1 - C6 C3, C6, among others R30 is H or c1-c4 alkyl R50 is H or c1-c4 alkyl.The preferred compounds are: acid 3 - (S) - 4 - [3-chloro-4 (3,3 - Dimethyl Butyl) - phenyl] - 5 - isopropyl - 4 - methyl - 2 - oxo - 3,4-dihydro - 2H - pyrimidine - il - 1} - propionic acid 4 - {5 Tert Butyl - 4 - [4 - (3 - Chloro - 2.2 - dimetilpropoxi) phenyl] - 2 - oxo - 3,4-dihydro - 2H - pyrimidine - il - 1} butanoic acid, among others. It also relates to a composition.This Compound is an inhibitor of retinoid related Orphan receptor gamma (rorgamma), being useful in the treatment of rheumatoid arthritis, psoriasis, among othersSe refiere a un compuesto derivado de dihidropirimidin-2-ona de formula (I) o una de sus sales farmaceuticamente aceptables, donde: R1 es alquilo C4-C8, alquilo C3-C8 sustituido con hidroxi, entre otros R2 es halogeno, alquilo C1-C6, entre otros R3 -Yb-COO-R30, alquilo C1-C6, entre otros n es un numero entero de 0 a 3 entre otros R4 es H, o metilo R5 es -Yc-COO-R50, H, entre otros R6 es metilo Yc es alquenileno C1-C6 opcionalmente sustituido, CH2-CH2-O-CH2, entre otros Yb es alquenileno C1-C6, cicloalquileno C3-C6, entre otros R30 es H o alquilo C1-C4 R50 es H o alquilo C1-C4. Entre los compuestos preferidos tenemos: Acido 3-{(S)-4-[3-cloro-4-(3,3-dimetil-butil)-fenil]-5-isopropil-4-metil-2-oxo-3,4-dihidro-2H-pirimidin-1-il}-propionico acido 4-{5-ter-butil-4-[3-cloro-4-(2,2-dimetilpropoxi)fenil]-2-oxo-3,4-dihidro-2H-pirimidin-1-il}-butanoico e
