Pirrolotriazinas refers to compounds of formula (i) where a is n or CR2, where R2 is H, F and Cl r1 is H, F, Methyl, Ethyl, among others Z is alkyl (c1-c4), cycloalkyl (C3 and C6), among others.Preferred compounds are: [4 - (7 - amino - propilpirrolo [2,1-f] [1,2,4] triazin - 5 - il) phenyl] methanol [4 - (7 - amino - propilpirrolo [2,1-f] [1,2,4] triazin - 5 - yl) - 2.6 - difluorofenil] methanol: {4 - amino - 5 - 3.5 - difluoro - [4 - (hydroxymethyl) phenyl] pirrolo [2,1-f] [1,2,4] triazin - il - 7} - (cyclopropyl Methanol among others). It also relates to a preparation method and a Pharmaceutical composition.These compounds are inhibitors of the Activin receptor like kinase 1 (ALK1) being useful in the treatment of age related Macular Degeneration (AMD), Choroidal Neovascularization (CNV), Diabetic Retinopathy, diabetic macular edema (EMD)SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLOTRIAZINAS DE FORMULA (I) DONDE A ES N O CR2, EN DONDE R2 ES H, F O Cl R1 ES H, F, METILO, ETILO, ENTRE OTROS Z ES ALQUILO(C1-C4), CICLOALQUILO(C3-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [4-(4-AMINO-7-PROPILPIRROLO[2,1-f][1,2,4]TRIAZIN-5-IL)FENIL]METANOL [4-(4-AMINO-7-PROPILPIRROLO[2,1-f][1,2,4]TRIAZIN-5-IL)-2,6-DIFLUOROFENIL]METANOL {4-AMINO-5-[3,5-DIFLUORO-4-(HIDROXIMETIL)FENIL]PIRROLO[2,1-f][1,2,4]TRIAZIN-7-IL}-(CICLOPROPIL)METANOL ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE ACTIVINA TIPO QUINASA-1 (ALK1) SIENDO UTILES EN EL TRATAMIENTO DE DEGENERACION MACULAR RELACIONADA CON LA EDAD (DME), NEOVASCULARIZACION COROIDEA (NVC), RETINOPATIA DIABETICA, EDEMA MACULAR DIABETICO (EMD)
