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Derivados de alquilfosfolípidos con citotoxicidad reducida y sus usos
专利权人:
ETERNA ZENTARIS GMBH
发明人:
PERRISSOUD, DANIEL,PIETRAS, MATHIAS,ENGEL, JUERGEN
申请号:
ES06847032
公开号:
ES2437996T3
申请日:
2006.12.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Use of an alkyl phospholipid derivative according to formula (I) ** ** Formula wherein: W, X, Y are independently selected from the group consisting of: "oxygen atom, sulfur atom" R1 is "-R5" R2 is "R8" R5 is independently selected from the group consisting of selected: "C8-C30 alkyl substituted or unsubstituted" R8 is selected from the group consisting of: "substituted or unsubstituted heterocyclic" wherein the heterocycle is (i) a ring system carbon atoms, monocyclic, saturated, partially unsaturated or aromatic 5, 6 or 7 members, at least one heteroatom selected from the group consisting of: "denitrógeno atom, oxygen atom, sulfur atom, arsenic atom", and with the proviso that at least unheteroátomo is a quaternary nitrogen atom or an atom quaternary arsenic. and wherein the heterocycle is substituted if is substituted with at least one R12 radical, which in the case of two or másradicales R12, are independently the same, partly the same or different R12 is independently selected from the group consisting of: "hydrogen atom, C1-C18sustituido or unsubstituted alkyl, C3-C8 substituted or unsubstituted (C1-C12) sb- (C1-C12) tC - (C1-C12) or substituted or unsubstituted aryl, substituted or unsubstituted, heteroaryl substituted or unsubstituted, alcoxisustituido or unsubstituted, -OH, halogen, -F, - Cl, -Br, -I,> = O, -C (O) O- (C1- C12 alkyl), -C (O) O- (C3-C8), - C (O) O-aryl, -C (O) O-heteroaryl, -C (O ) O-heterocyclyl, -C (O) - (C1-C12), -C (O) - (C3-C8), -C (O) -aryl, -C (O) -heteroaryl, -C ( O) -heterocyclyl " B, C are independently selected from the group consisting of "oxygen atom sulfur atom S (O2)" s, t, u are independently 0 or 1 for the manufacture of a medicament for the treatment or prophylaxis of diseases and / or afeccionesfisiopatológicas in mammals that are caused by a fungus selected from the group consisting of "Absidia spp., Acremonium spp., Alternaria spp., Aspergillus spp., Bipolaris spp., Candida spp., Cladophialophora spp., Cladosporium spp.,
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