COOYMANS, Ludwig Paul,HU, Lili,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard,TAHRI, Abdellah,VAN HOOF, Steven Maurice Paula,VENDEVILLE, Sandrine Marie Helene
申请号：
ES11796711
公开号：
ES2624282T3
申请日:
2011.12.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that satisfies the formula I, N-oxide, addition salt, quaternary amine, metal complex, or an isomeric stereochemical form thereof； formula I wherein each X is independently C or N； each Y is independently C or N； R1 is present when X>； = C and R1 is selected from the group of H, halogen, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, N (R5) 2, CO (R6), CH2NH2, CH2OH, CN , C (>； = NOH) NH2, C (>； = NOCH3) NH2, C (>； = NH) NH2, CF3, OCF3, and B (OH) 2； B (O-C1-C6 alkyl) 2； R1 is absent when X>； = N R2 is selected from the group consisting of H, halogen, - (CR7R8) n-R9, C≡C-CH2-R9 and C≡C-R9, CH>； = CH-R9 R3 is selects from the group consisting of H, C1-C10 alkyl, C3-C7 cycloalkyl, C2-C10 alkenyl, SO2-R7, or a saturated 4 to 6 membered ring containing an oxygen atom； R4 is present where Y is C and is selected from the group consisting of H, C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 alkoxy, CO (R7), CF3 and halogen, R5 is selected from the group consisting of H , C1-C6 alkyl, COOCH3, and CONHSO2CH3； R6 is selected from the group consisting of OH, O (C1-C6 alkyl), NH2, NHSO2N (C1-C6 alkyl) 2, NHSO2NHCH3, NHSO2 (C1-C6 alkyl), NHSO2 (C3-C7 cycloalkyl), and N ( C1-C6 alkyl) 2； R7 and R8 are each independently selected from H, C1-C10 alkyl, C3-C7 cycloalkyl, or R7 and R8 taken together form a 4 to 6 membered aliphatic ring that optionally contains at least one heteroatom selected from the group of N, S , OR； R9 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl OH, CN, F, CF2H, CF3, CONR7R8, COOR7, CON (R7) SO2R8, CON (R7) SO2N ( R7R8), NR7R8, NR7COOR8, OCOR7, NR7SO2R8, SO2NR7R8, SO2R7 or a saturated 4- to 6-membered ring containing an oxygen atom； n is an integer from 2 to 6.Un compuesto que satisface la fórmula I, N-óxido, sal de adición, amina cuaternaria, complejo metálico, o una forma estereoquímica isómera del mismo； fórmula I en donde cada X es independientemente C o N； cada Y es independientemente C o N； R1 está pr
