KU, YIYIN,OR, YAT SUN,WAGAW, SABLE H.,ENGSTROM, KEN,GRIEME, TIM,SHEIKH, AHMAD,MEI, JIANZHANG,MCDANIEL, KEITH F.,CHEN, HUI-JU,SHANLEY, JASON P.,KEMPF, DALE J.,GRAMPOVNIK, DAVID J.,SUN, YING,LIU, DONG,G
申请号：
ES12160779
公开号：
ES2525922T3
申请日:
2009.09.10
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I or I ': ** Formula ** or a pharmaceutically acceptable salt thereof for use in the treatment of HCV infection in a subject, where: J is -C (O) - or -OC (O )； A is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, heterocyclic of 5 to 10 ring atoms or C3-C10 carbocyclic, and A is optionally substituted with one or more R6； each R1 and R2 is independently selected from (i) halogen, hydroxy, amino, -CN, -CF3, -N3, -NO2, -OR4, -SR4, -SOR4, -SO2R4, -NR3R4, -C (O) - O-R4, -C (O) R4, -C (O) NR3R4 or -N (R3) C (O) R4； (ii) heterocyclic of 5 to 10 ring atoms and optionally substituted with one or more R7； (iii) C3-C10 carbocyclic optionally substituted with one or more R7； or (iv) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl； G is -E-R5； where E is -NHS (O2) -； R5 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 carbocyclic, heterocyclic of 5 to 10 ring atoms or heteroaryl, and each R5 is optionally substituted with one or more R7； R3 and R4 are each independently selected in each case from hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl； L is C3-C6 alkylene, C3-C6 alkenylene or C3-C6 alkynylene and is optionally substituted with one or more R7； j>； = 0； k>； = 0； m>； = 1； n is 0, 1, 2, 3 or 4； and represents a single bond or a carbon-carbon double bond； Y is -C (R ")； R 'and R", taken together with the carbon atoms to which they are attached, form an aryl or heteroaryl ring, which is eventually substituted with one or more R2； each R6 and R7 is independently selected in each case from halogen, hydroxy, amino, -CF3, -CN, -N3, -NO2, -C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl or C2-C6 haloalkynyl.Un compuesto de fórmula I o I':**Fórmula** o una sal del mismo farmacéuticamente aceptable para uso en el tratamiento de la infección por VHC en un sujeto, donde: J es -C(O)- u -O-C(O)； A es alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, arilo,
