A compound of Formula (Va): ** Formula ** or a pharmaceutically acceptable salt, solvate, tautomer, stereoisomer or analogue thereof, wherein: R1 is H, halogen, C1-C6 alkyl deuterated, alkyl C1-C6, aryl, C1-C4 arylalkyl, C3-C8 cycloalkyl, (C3-C6) cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with 1-3 Rj groups, wherein two Rj substituents when anchored to adjacent atoms of the aryl, heteroaryl, cycloalkyl or heterocycloalkyl ring are optionally taken together to form a 5 or 6 membered ring having 0 to 2 heteroatoms selected from O, N or S, wherein the 5 or 6 member ring is optionally substituted with 1-3 Rh groups； or two Rj groups when anchored to the same carbon or nitrogen atom are optionally taken together to form a 3 to 6 membered carbocyclic ring or a 3 to 8 membered heterocyclic ring having 1 to 2 heteroatoms as ring members selected from O , N or S, where the nitrogen or sulfur ring atoms are optionally oxidized； R2 is H； R3 is halogen, -CN, -CD3, deuterated C1-C6 alkyl, C1-C6 alkyl, aryl, C1-C4 arylalkyl, heteroaryl, C1-C4 heteroarylalkyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, C3-C8 cycloalkyl ) C1-C4 alkyl, C2-C6 alkynyl, heterocycloalkyl, heterocycloalkylalkyl C1-C4 or Rj, wherein each of R3 is optionally substituted with 1-3 Rh substituents or 1 to 3 Rm groups independently selected from CN, -OH, -NH2, -NO2, -C (O) OH, -C (S) OH, -C (O) NH2, -C (S) NH2, -S (O) 2NH2, -NHC (O) NH2, -NHC (S) NH2, -NHS (O) 2NH2, -C (NH) NH2, -B (OH) 2, -Si (Rn) 3, -CH>； = C (Rn) (Rn), -ORn, -SRn , -OC (O) Rn, -OC (S) Rn, -P (>； = O) HRn, -P (>； = O) RnRn, -PH (>； = O) ORn, -P (>； = O) ( ORn) 2, -OP (>； = O) (ORn) 2, -C (O) H, -O (CO) ORn, -C (O) Rn, -C (S) Rn, -C (O) ORn , -C (S) ORn, -S (O) Rn, -S (O) 2Rn, -C (O) NHRn, -C (S) NHRn, -C (O) NRnRn, -C (S) NRnRn, -S (O) 2NHRn, -S (O) 2NRnRn, -C (NH) NHRn, -C (NH) NRnRn, -NHC (O) Rn, -NHC (S) Rn, -NRnC (O) Rn,
