COOYMANS, Ludwig Paul,DEMIN, Samuël Dominique,HU, Lili,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard,TAHRI, Abdellah,VENDEVILLE, Sandrine Marie Helene
申请号：
ES11799682
公开号：
ES2624263T3
申请日:
2011.12.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that satisfies the formula I, an N-oxide, an addition salt, a quaternary amine, a metal complex or a stereochemically isomeric form thereof: ** Formula ** wherein each of the X is independently C or N , where N is at least one X； one Y is N and the other Y's are C； R1 is present when X>； = C and R1 is selected from the group of H, OH, halogen, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, - (R6) 2, CO (R7), CH2NH2, CH2OH , CN, C (>； = NOH) NH2, C (>； = NOCH3) NH2, C (>； = NH) NH2, CF3, OCF3 and B (OH) 2； B (O-C1-C6 alkyl) 2； R2 is selected from the group consisting of H, halogen, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy and CO (R7)； R3 is - (CR8R9) n-R10； R4 is selected from the group consisting of H, C1-C10 alkyl, CH2CF3, C3-C7 cycloalkyl, C2-C10 alkenyl, SO2-R8, or a saturated 4 to 6 membered ring containing an oxygen atom； R5 is present when Y is C, and is selected from the group consisting of H, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, CO (R7), CF3 and halogen； R5 is absent when Y is N； R6 is selected from the group consisting of H, C1-C6 alkyl, COOCH3 and CONHSO2CH3； R7 is selected from the group consisting of OH, O (C1-C6 alkyl), NH2, NHSO2N (C1-C6 alkyl) 2, NHSO2NHCH3, NHSO2 (C1-C6 alkyl), NHSO2 (C3-C7 cycloalkyl) and N (alkyl C1-C6) 2； n is an integer from 2 to 6； R8 and R9 are each independently selected from H, C1-C10 alkyl, C3-C7 cycloalkyl or R8 and R9 taken together form a 4- to 6-membered aliphatic ring optionally containing a heteroatom selected from the group N, S, O ； R10 is selected from the group consisting of H, C1-C6 alkyl, OH, CN, F, CF2H, CF3, CONR8R9, COOR8, CONR8SO2R9, CON (R8) SO2N (R8R9), NR8R9, NR8COOR9, OCOR8, NR8SO2R9, SO2NR8R9, SO2R8 or a saturated 4 to 6 member ring containing an oxygen atom.Un compuesto que satisface la fórmula I, un N-óxido, una sal por adición, una amina cuaternaria, un complejo metálico o una forma estereoquímicamente isomérica del mismo:**Fórmula** en donde cada uno de los X es independie
