TAHRI, Abdellah,VENDEVILLE, Sandrine Marie Helene,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard,HU, Lili,DEMIN, Samuël Dominique,COOYMANS, Ludwig Paul
申请号：
ES13779195
公开号：
ES2640446T3
申请日:
2013.10.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (RI), ** Formula ** or any of its stereoisomeric forms, where: Het is a heterocycle with any of the following formulas (a), (b), (c), (d): ** Formula ** each X is independently C or N； provided that at least two X are C； each of the groups R1a, R1b, R1c or R1d is independently selected from the group consisting of H, halogen, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkyloxy, N (R6) 2, CO (R7), CH2NH2 , CH2OH, CN, C (>； = NOH) NH2, C (>； = NOCH3) NH2, C (>； = NH) NH2, CF3 and OCF3； R1b or R1d will be absent when the X atom to which it is attached is N； each R2 is - (CR8R9) m-R10； m is an integer from 0 to 6； each R3 is independently selected from the group consisting of H, halogen, aryl, heteroaryl, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkyloxy and CO (R7)； each R6 is independently selected from the group consisting of H, C1-C6 alkyl, COOCH3 and CONHSO2CH3； each R7 is independently selected from the group consisting of H, C1-C6 alkyl, OH, C1-C6 alkyloxy, NH2, NHSO2N (C1-C6 alkyl) 2, NHSO2NHCH3, NHSO2 (C1-C6 alkyl), NHSO2 (C3-C7 cycloalkyl ) and NR9R10； each R8 and R9 is independently selected from the group consisting of H, C1-C10 alkyl and C3-C7 cycloalkyl； or R8 and R9, taken together, form a saturated ring of 4 to 6 members optionally containing one or more heteroatoms selected from the group consisting of N, S and O； each R10 is independently selected from the group consisting of H, halogen, OH, CN, CF2H, CF3, C1-C6 alkyl, C3-C7 cycloalkyl, C (>； = O) (C1-C6 alkyl), C (>； = O) (C3-C7 cycloalkyl), C (>； = O) NR8R9, C (>； = O) OR8, SO2R8, C (>； = O) N (R8) SO2R9, C (>； = O) N (R8) SO2N (R8R9 ), NR8R9, NR8C (>； = O) OR9, OC (>； = O) R8, O-benzyl, NR8SO2R9, SO2NR8R9, SO2R8, OC (>； = O) NR8R9, OC (>； = O) NR8R12, N (R8) C (>； = O) N (R8R9), R11, N (R8) C (>； = O) OR12, OR11, C (>； = O) R11 and a saturated 4- to 6-membered ring containing an oxygen atom； R11 is phenyl, pyridinyl or pyrazolyl； each of which may be optio
