A pharmaceutical composition comprises a polyethylene glycol having a molecular weight in the range from about 1,000 to about 10,000, and a water-soluble cellulose derivative having a molecular weight in the range from about 50,000 to 120,000. The composition can further comprise boric acid and/or phosphate, a non-ionic surfactant, and/or an ophthalmic therapeutic agent. The composition is effective in treating, controlling, ameliorating, or reversing one or more conditions or symptoms of dry eye.本發明係關於一種醫藥組合物,其包含分子量約1,000至約10,000範圍內之聚乙二醇及分子量約50,000至120,000範圍內之水溶性纖維素衍生物。該組合物可進一步包含硼酸及/或磷酸鹽、非離子型界面活性劑及/或眼用治療劑。該組合物在治療、控制、改善或逆轉乾眼症之一或多種病狀或症狀是有效的。