The present invention relates to an ophthalmic pharmaceutical composition comprising at least one liposome and a therapeutic agent for treating an eye disease with a high drug to lipid ratio and encapsulation efficiency. Also provided is the method for treating age-related macular degeneration or diabetic eye disease using the ophthalmic pharmaceutical composition disclosed herein.本發明關於一種具有高藥物脂質比及高包埋效率的眼用藥物組合物,所述眼用藥物組合物包含至少一微脂體及用於治療眼部疾病之治療劑。本發明亦提供使用本文所揭露的眼用藥物組合物用於治療老年性黃斑部病變或糖尿病眼部疾病的方法。