The invention relates to compositions and methods for treating eye diseases and disorders. More specifically, the invention provides compositions comprising progesterone and methods of treating ocular surface diseases and disorders comprising applying such compositions topically.本發明係關於一種治療眼部疾病或異常的組合物及方法。更具體地說,本發明係提供包含黃體酮之組合物,以及包含局部性施予該組合物以治療眼表疾病和異常之步驟的方法。