The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.本申請案關於新穎的經取代哌啶基吡唑并嘧啶酮、關於其製備方法、在一方法中單獨或合併使用該化合物治療及/或預防疾病，尤其用於治療及/或預防有或無潛在遺傳性或後天性凝血失常之患者的急性和反覆出血，其中該出血係和選自由下列所構成之群組的疾病或醫療干預有關：大量經期出血、產後失血、失血性休克、出血性膀胱炎、胃腸道出血、創傷、手術、移植、中風、肝病、遺傳性血管水腫、鼻血、與關節積血之後的滑膜炎與軟骨損傷。
