An objective of the present invention is to provide an effective pharmaceutical composition or a dosage regimen for preventing and/or treating bleeding, a disease accompanying bleeding, or a disease caused by bleeding. The inventors discovered that by administering a pharmaceutical composition comprising a bispecific antigen-binding molecule that recognizes (a) blood coagulation factor IX and/or activated blood coagulation factor IX and (b) blood coagulation factor X and/or activated blood coagulation factor X according to a given dosage regimen, bleeding, a disease accompanying bleeding, or a disease caused by bleeding can be prevented and/or treated more effectively.本發明的目的之一為提供有效的醫藥組合物或給藥方案，其用於預防和/或治療出血、伴隨出血的疾病或出血導致的疾病。發明人發現根據給予的給藥方案，透過給予醫藥組合物，其包含辨認(a)凝血因子IX和/或活化的凝血因子IX，以及(b)凝血因子X和/或活化的凝血因子X的雙特異性抗原結合分子，能較有效地預防和/或治療出血、伴隨出血的疾病或出血導致的疾病。
