TAIWAN LIPOSOME CO. LTD.;TLC BIOPHARMACEUTICALS, INC.
发明人:
HONG, KEELUNG,洪基隆,GUO, LUKE S. S.,郭松声,郭松聲,SHIH, SHEUE FANG,施雪芳,CHANG, PO CHUN,张博钧,張博鈞,TSAI, CHIH CHIANG,蔡志强,蔡志強,LIN, HONG HUI,林宏辉,林宏輝,TSENG, YUN LONG,曾云龙,曾雲龍
申请号：
TW102105245
公开号：
TWI620578B
申请日:
2013.02.08
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid or a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5umol per 50ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.本發明是關於包含下列組合的藥學組成物:此組成物包含一或多種磷脂質及帶有或不帶有膽固醇的脂質混合物,以及包含眼用類固醇、其藥用的鹽類或其前驅藥的類固醇溶液,該藥學組成物中磷脂質的總量是每50μL的藥學組成物含有大約0.1μmol至低於大約2.5μmol,並且該組成物會減少眼用類固醇的副作用。該藥學組成物較適用藉由眼睛投藥途徑來治療眼科疾病。
