5-substituted-2-phenylamino benzamides as MEK inhibitors

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专利权人:

Hitoshi Iikura;Kosuke Aso;Masanori Miwa;Yasuaki Matsubara;Shinji Tsujii;Yoshiaki Isshiki;Yasunori Kohchi;Takeshi Murata;Nobuo Shimma;Masami Kohchi;Eisaku Mizuguchi;Satoshi Aida

发明人:

Yoshiaki Isshiki,Yasunori Kohchi,Eisaku Mizuguchi,Hitoshi Iikura,Yasuaki Matsubara,Shinji Tsujii,Nobuo Shimma,Masanori Miwa,Satoshi Aida,Masami Kohchi,Takeshi Murata,Kosuke Aso

申请号：

US12752396

公开号：

US08575391B2

申请日:

2010.04.01

申请国别(地区):

US

年份:

2013

代理人:

摘要：

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases.The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1):[where R1, R2, R3, R4, and X are the same as defined in the present patent application].

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