5-SUBSITUE-2-PHENYLAMINE BENZAMIDE AGISSANT EN TANT QU'INHIBITEUR MEK

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

ISSHIKI, YOSHIAKI,KOHCHI, YASUNORI,MIZUGUCHI, EISAKU,IIKURA, HITOSHI,MATSUBARA, YASUAKI,TSUJII, SHINJI,SHIMMA, NOBUO,MIWA, MASANORI,AIDA, SATOSHI,KOHCHI, MASAMI,MURATA, TAKESHI,ASO, KOSUKE

申请号：

CA2575232

公开号：

CA2575232C

申请日:

2005.07.26

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

An objective of the present invention is to provide compounds that exhibitstrongMEK-inhibiting activity and are stable in vivo and soluble in water, which canbe used aspreventive or therapeutic agents for proliferative diseases.The compounds of the present invention and pharmaceutically acceptable saltsthereof arerepresented by the following formula (1):(see formula 1)[where R1, R2, R3, R4, and X are the same as defined in the present patentapplication].

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