The United States of America; as represented by the Secretary of the Department of Health and Human Services
发明人:
Stephen S. Whitehead,Joseph E. Blaney,Brian R. Murphy,Ching-Juh Lai
申请号：
US13692557
公开号：
US09090873B2
申请日:
2012.12.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′direction as far as the 5′boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR； and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
