Inviragen, Inc.;The United States of America as Represented by the Secretary of Health and Human Services
发明人:
Jill A. Livengood,Claire Y. Huang,Timothy D. Powell,Dan T. Stinchcomb,Jorge Osorio
申请号：
US14076034
公开号：
US09408901B2
申请日:
2013.11.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Embodiments herein report compositions, methods and uses for dengue-4 (DENV-4) virus constructs. Some embodiments concern a composition that includes, but is not limited to, DENV-4 virus constructs alone or in combination with other constructs, can be used in a vaccine composition to induce an immune response in a subject. In certain embodiments, compositions can include constructs of more than one serotypes of dengue virus, such as dengue-1 virus, dengue-2 virus, or dengue-3 virus in combination with DENV-4 virus constructs disclosed herein. In other embodiments, DENV-4 constructs disclosed herein can be combined in a composition with other flavivirus constructs to generate a vaccine against more than one flavivirus. Other embodiments provide methods and uses for DENV-4 virus constructs in vaccine compositions that when administered to a subject induce an immune response in the subject against DENV-4 that is improved by modified constructs compared to other vaccine compositions.
